Sporadic primary hyperparathyroidism

Molecular Alterations in Sporadic Primary Hyperparathyroidism

Primary hyperparathyroidism (PHPT) is a frequent endocrine disorder characterized by an excessive autonomous production and release of parathyroid hormone (PTH) by the parathyroid glands. This endocrinopathy may result from the development of a benign lesion (adenoma or hyperplasia) or from a carcinoma. Most of the PHPT cases occur sporadically; however, approximately 10% of the patients presen...

Primary hyperparathyroidism – sporadic and hereditary forms – etiology and pathogenesis

Medication discontinuation after curative surgery for sporadic primary hyperparathyroidism.

BACKGROUND Although parathyroidectomy (Ptx) for sporadic primary hyperparathyroidism (PH) improves comorbidities and symptoms, routine Ptx for minimally symptomatic PH remains controversial. Whether successful Ptx translates into discontinuation or dose-reduction of prescribed medications is unknown. METHODS Consecutive patients undergoing curative Ptx for sporadic PH from January 2007 to Apr...

Sporadic primary hyperparathyroidism in young patients: a separate disease entity?

HYPOTHESIS Sporadic primary hyperparathyroidism (1 HPT) in young persons is thought to be extremely rare. The exact incidence is unknown and little is known of the characteristics of the disease. METHODS From 1976 to 1998, 33 patients aged 19 years or younger underwent operation for sporadic 1 HPT at a single institution. Data were recorded regarding the clinical, surgical, pathologic, and bi...

Immunologic Differentiation of Primary Hyperparathyroidism from Hyperparathyroidism

A B S T R A C T Serum immunoreactive parathyroid hormone (IPTH) was measured by radioimmunoassay in 54 patients with primary hyperparathyroidism and in 18 consecutive patients with ectopic hyperparathyroidism due to nonparathyroid cancer without apparent skeletal metastasis. Although serum calcium concentration was higher in the group with ectopic hyperparathyroidism, serum IPTH was lower (rank...